Given its secluded location, the street has been described as "the hidden wonder of the West End"[1] and it was voted Best Street in London in 2002 by listeners of BBC Radio 4, winning praise for its being "a haven in the middle of the frantic city.

"[2] Marylebone High Street was also an electoral ward of the City of Westminster from 2002 to 2022; its population at the 2011 Census was 10,366.

[4] Marylebone Gardens, on the east side of the street, was opened officially in 1738; it included a stylish concert venue which attracted eminent composers such as George Frideric Handel and James Hook.

The entrance to the Gardens was through the Rose Tavern, a public house on 35-36 Marylebone High Street, which was the home of BBC London until September 2009 when it moved to BBC Broadcasting House.

It has been credited with turning a "once-shabby area of central London" into an elegant street, which carefully manages its "mix of boutiques and small retailers.