Masonic College was a higher education institution in the U.S. state of Missouri that was established by Freemasons in 1844 and operated until 1857.
During the American Civil War Battle of Lexington I, the building and grounds served as Federal headquarters for the forces under Colonel James A. Mulligan, who surrendered after a three-day siege, September 18–20, 1861.
It was later abandoned by the Missouri State Guard, and the college was used by Federal troops for the remainder of the war.
Soon after the conclusion of the war, the building and grounds were transferred to the state, and a military institute was opened, but that school failed as well.
The replica building, which still stands, was dedicated May 18, 1934, in a ceremony led by Grand Master Frank Clinton Barnhill.