[5] Keiko Agena, Shohreh Aghdashloo, Erika Alexander, Kendra Andrews, Logan Arens, Dylan Baker, Kuno Becker, Cleo Berry, Thom Bishops, J.R. Cacia, Erin Cahill, Hayley Chase, Michael Chey, Gabrielle Christian, Justin Chon, Willis Chung, Austin Michael Coleman, Jack Coleman, David Costabile, Stephanie Courtney, Kevin Daniels, Michelle DeFraites, Brett DelBuono, Tiffany Espensen, Kayla Ewell, Chad Faust, Lesley Fera, Andrew Fiscella, Megan Follows, Ken Garito, Sprague Grayden, Joyce Greenleaf, Jennifer Grey, Matthew Haddad, Tina Holmes, Amy Irving, Brittany Ishibashi, Ashley Jones, Zachary Knighton, Amy Landecker, Jennifer Landon, Adrian LaTourelle, James Hiroyuki Liao, Matthew Lillard, Seidy Lopez, Donal Logue, Stella Maeve, Terry Maratos, Chris Marquette, Gerald McCullouch, Rachel Melvin, Brigdett Newman, Linda Park, Kimberlee Peterson, Kevin Phillips, Haley Pullos, Aaron Refvem, Allan Rich, Sasha Roiz, Tony Savas, Vinessa Shaw, Samantha Smith, Alyson Stoner, Tyler James Williams, Jarret Wright and George Wyner.
House and Cuddy take the day off to talk about their new relationship, while the team tries to cure the lone neurosurgeon (George Wyner) on staff who must be ready to operate.
Final diagnosis: Sickle cell trait House and his team race against time to help an author (Amy Irving) who suffered a seizure while attempting to kill herself.
Meanwhile, Foreman and Taub must both find a female replacement for Thirteen, and House and Wilson learn valuable lessons in babysitting when Cuddy has to work late.
Abbey's baby: hereditary melanoma Brilliant medical student Martha M. Masters (Amber Tamblyn) joins the team at Cuddy's insistence, and her first case is treating a campaign manager (Jack Coleman) who falls ill with a rash, leading to liver failure.
Final Diagnosis: Hepatitis C A teenage girl (Hayley Chase) comes to the hospital displaying classic smallpox symptoms, which the team dismisses as impossible until her step-father (Andrew Fiscella) gets sick as well.
Final Diagnosis: Rickettsialpox House must battle disease as well as belief when his patient (Kuno Becker) gets sick after crucifying himself as part of a bargain with God to keep his daughter cancer-free.
Final Diagnosis: Marburg multiple sclerosis and Rhodococcus equi infection secondary to malnutrition When a bassist (Matthew Lillard) passes out after saving a woman in a subway station, the team must treat him amidst his newfound celebrity, while he begins to realize he may be a better man than he believed.
Meanwhile, House must survive a dinner with Cuddy's mother (Candice Bergen), and Taub comes to terms with his marriage after he is featured in an ad for the hospital.
Final Diagnosis: Chickenpox A drill sergeant (Sasha Roiz) at a camp for troubled kids collapses with severe back pain, and House and the team must find a connection when one of his recruits (Tyler James Williams) falls ill with the same symptoms.
Final Diagnosis: Variegate porphyria Cuddy's mother (Candice Bergen) is rushed to the hospital with heart problems, but refuses treatment by House.
Final Diagnosis: Cobalt poisoning secondary to metallosis A woman (Tina Holmes) comes to the hospital with temporary paralysis, but it is her perfect memory which compels House to take the case.
Final Diagnosis: McLeod syndrome causing obsessive–compulsive disorder House attends a career day at an elementary school as a favor so Rachel can get accepted.
Final Diagnosis: Food lodged in the lung A real estate higher-up (Adrian LaTourelle) is admitted to the hospital with a severe rash, but it soon becomes clear that he does not live the life that he has led his wife to believe.
Cuddy: Benign tumor in the kidney; antibiotic allergy Newly single and back on Vicodin, House gives himself the five-star treatment but begins to worry that nothing – not even medical puzzles – can excite him anymore.
[a] The team takes on the case of a lottery winner (Donal Logue) suffering from paralysis and multiple types of cancer, and they must figure out if it is his new millionaire lifestyle that is making him sick.