Matheson is a census-designated place (CDP) and post office in and governed by Elbert County, Colorado, United States.

The Matheson post office has the ZIP Code 80830.

[4] At the United States Census 2020, the population of the Matheson CDP was 79.

The United States Census Bureau defined the Matheson CDP for the United States Census 2020.The television series Honey, I Shrunk the Kids: The TV Show is set in Matheson, Colorado.

However, the series portrays Matheson as much larger, a hub of high-tech industry, and located somewhere in the mountains west of Denver.