Matsatu Creek, historically called the Matsatu River, is a tributary of Kakuchuya Creek and part of the Taku River watershed in northwest part of the province of British Columbia, Canada.

[1][6] It is located 40 km (25 mi) north of the abandoned settlement of Sheslay in Cassiar Land District.

From its source at Level Mountain, where it has cut a large gorge into its western escarpment, Matsatu Creek flows generally north and west for roughly 35 km (22 mi)[4] to join Kakuchuya Creek, the main tributary of the Dudidontu River.

[2][11][12] From its source Matsatu Creek flows north and west through a large gorge in the western escarpment of Level Mountain.

As it continues flowing through the Nahlin Plateau, it collects numerous unnamed tributary streams.