By his senior year, when he had a 1.91 earned run average (ERA) and 77 strikeouts in 40+1⁄3 innings pitched, his fastball could reach 99 miles per hour (159 km/h).

[8] In 2017, Manning began the season in extended spring training, and spent time with both the Connecticut Tigers of the Low–A New York-Penn League and the West Michigan Whitecaps of the Single–A Midwest League,[9] pitching to a combined 4–2 record and 3.18 ERA in 14 total starts between both teams.

[17] Manning had a 7–8 record with a 3.29 ERA and a 1.20 walks plus hits per innings pitched ratio in 22 total starts between the three clubs.

[20] On January 16, 2020, he was a non-roster invitee of the Detroit Tigers to Spring Training before the season was postponed due to the coronavirus.

[24] In his next start on June 23, his home debut for the Tigers, Manning earned his first major league win over the St. Louis Cardinals, allowing two runs over 5+2⁄3 innings.

[26] On August 24, Manning pitched six shoutout innings with a career-high eight strikeouts in a win over the San Francisco Giants.

[29] On July 8, Manning pitched the first 6.2 innings of a combined no-hitter with relief pitchers Jason Foley and Alex Lange against the Toronto Blue Jays.

[31] Manning was optioned to Triple–A Toledo to begin the 2024 season after Casey Mize and Reese Olson won the final rotation spots.