Miller graduated from Trinity High School, where he was a pitcher and outfielder,[1] in 1991 and was named Kentucky's Mr.

Miller began his professional career in 1991 with the rookie level Bristol Tigers, where in 13 starts, he went 2–7 with a 5.67 ERA.

He made his major league debut on September 4, 1996, against the Chicago White Sox, pitching 1+1⁄3 innings, giving up 2 earned runs, and taking the loss.

On January 22, 2001, Miller signed a minor league contract with the Boston Red Sox and pitched as both a starter and reliever for Triple-A Pawtucket.

He pitched in 76 games without earning a win or taking a loss, shattering the mark Aldred had set at 48 in 1998 as a member of the Tampa Bay Devil Rays.

On December 3, 2008, Miller signed a one-year incentive-laden deal worth potentially $2 million with the St. Louis Cardinals.

On July 27, 2011, he was traded to the Toronto Blue Jays along with P. J. Walters, Brian Tallet and Colby Rasmus for Edwin Jackson, Octavio Dotel, Marc Rzepczynski and Corey Patterson.

[9] On August 30, 2011, Miller signed a minor league contract with the Boston Red Sox and assigned to Triple-A Pawtucket.

On January 30, 2012, Miller signed with the Chicago Cubs in a minor league deal, with a spring training invitation.

All proceeds made from the run are donated to the Kiwanis of Gulf Beaches Miracle League, which is a baseball related charity associated with children with disabilities.