At international level, he was an unused member of the Italy national team that took part at the 2014 FIFA World Cup, and made his senior debut later that year.

Born in Latina and a product of the Genoa youth system, Perin was promoted to first team squad in January 2010, as a third-choice goalkeeper, and received the 88 jersey.

[14][15] Due to the return of Buffon as a back-up to Szczęsny, Perin was relegated to the role of the club's fourth goalkeeper, behind Carlo Pinsoglio; as such, in September, he was subsequently excluded from Juventus's 22–player Champions League squad by manager Maurizio Sarri.

Perin received his first call up for the Italian senior team by head coach Cesare Prandelli, for the friendly match against England held on 15 August 2012 in Bern; seven other new faces were in the squad.

[30] He made his debut with the national team on 18 November 2014, in a 1–0 friendly win against Albania, replacing Sirigu for the last 17 minutes at his club ground of the Stadio Luigi Ferraris.

[31] On 9 April 2016, he suffered an injury with Genoa in which he tore his anterior cruciate ligament and damaged his meniscus in his right knee, which would cause his absence as Italy's third goalkeeper at the UEFA Euro 2016.

[33] Considered one of the most promising young Italian players of his generation in his position, Perin is an agile, athletic, and dynamic keeper, who is highly regarded for his excellent reactions, shot-stopping ability, positional sense, bravery, and consistency; possessing good technique, he is gifted with strong all-round fundamental goalkeeping skills, and is also known for his speed to get to ground and ability to come off his line to collect the ball.

Standing at 1.88 m (6 ft 2 in), although he is not the tallest shot-stopper, he is gifted with an excellent spring, a large frame, and a long reach, which aids him in commanding his area, claiming or punching out crosses, and also enables him to produce spectacular, acrobatic, diving saves.