Maussane-les-Alpilles (French pronunciation: [mosan le.z‿alpij]; Occitan: Maussana deis Aupilhas; Provençal: Maussano lis Aupiho) is a commune in the Bouches-du-Rhône department in the Provence-Alpes-Cote d'Azur region in Southern France.

Part of Alpilles Regional Natural Park,[3] it is located between Saint-Rémy-de-Provence to the north and Saint-Martin-de-Crau to the south.

The commune of Maussane-les-Alpilles is situated on the southern slopes of the Alpilles in the heart Alpilles Regional Natural Park.

It is bound by the rocky ridges and crests of the Entreconque on the north as well as the north rim of the Crau on the south.