The species was described by Pinacho-Pinacho, Hernández-Orts, Sereno-Uribe, Pérez-Ponce de León & García-Varela om 2017.

[1] Phylogenetic analysis has been conducted based on the cox1 gene, and the 28S ribosomal RNA gene were conducted to compare with other species of Neoechinorhynchidae, confirming its correct family, however it determined that Neoechynorhynchus is not monophyletic.

The worm has a short trunk with a body wall containing five dorsal and one ventral giant hypodermal nuclei.

This stage involves penetrating the wall of the mesenteron or the intestine of the intermediate host and growing.

[1] There are no reported cases of M. karlae infesting humans in the English language medical literature.