Mayfield Independent City School District was established on July 1, 1908, with the selection and meeting of its first board members, organized by Mr. W.J.

A new stadium was built behind the high school and dedicated on November 6, 1925, at the Madisonville/Mayfield Game.

Up to this point, games were played at Cyclone Park, which was in the far north corner of what was Maplewood Cemetery.

[4] The school was used as a safe shelter for survivors during the 2021 tornado, which destroyed much of Mayfield.

[5] Mayfield High School has won 13 KHSAA football championships (1977, 1978, 1985, 1986, 1993, 1995, 2002, 2010, 2012, 2013, 2014, 2015, and 2023).