When the original 10-story Mayo Building was completed in 1955 by designers of Ellerbe & Co., it had been the largest construction project undertaken by Mayo.

The Mayo Clinic features artwork by many famous artists such as Andy Warhol.

[3] On June 20, 2007, the T. Denny Sanford Pediatric Outpatient Center opened, funded mostly by a $15-million gift from T. Denny Sanford, a credit card issuer and banker from South Dakota.

The center is on the 16th floor of the Mayo Building and houses many pediatric subspecialty staff, who were previously spread out across the clinic.

The floor's theme is upper midwest habitat.