Mazapil is a locality in the Mexican state of Zacatecas.

[2] The original inhabitants of the Mazapil valley were nomadic Chichimeca peoples known to the Spaniards as Guachichiles.

In 1562, Pedro de Ahumada y Samano reported finding the valley inhabited by 6000 native warriors armed with bows and arrows.

[3] Mazapil became the seat of its namesake municipality, which was one of Zacatecas's eleven original subdivisions (then known as partidos) when the state's constitution was enacted in 1825.

[6] The main economic activities in Mazapil are mining and agriculture.