Mazzano Romano is a comune (municipality) in the Metropolitan City of Rome in the Italian region of Latium, located about 35 kilometres (22 mi) north of Rome.

Mazzano Romano borders the following municipalities: Calcata, Campagnano di Roma, Castel Sant'Elia, Faleria, Magliano Romano, Nepi.

First mentioned in 945, it is one of the villages that formed from the great estate assembled by Pope Adrian I about 780, his Domusculta Capracorum.

[4] It includes the Regional Park of Veii.

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