The Mbirurume rises in forested country in southern Rwanda to the east of the Congo-Nile Divide.

[1] It originates in the extreme north of the Nyungwe National Park, in the Nyamagabe District.

It flows in a northeast direction, entering Karongi District and passes Mukungu to the west, then runs in a northeast direction along the border between Nyamagabe and Karongi districts.

It then turns southeast shortly before meeting the Mwogo River from the left.

This article related to a river in Rwanda is a stub.