The creek flows southeast into Dease River and is south of Good Hope Lake.
A camp, called Centreville, contained cabins and stores and served as a trading centre for miners working on McDame Creek in the 19th century.
In 1877, a 72-ounce (2.04-kg) solid gold nugget, valued at $1,300, was found in McDame Creek.
The lead was a run of gold that was 30 meters wide and continuous for almost a 1.5 kilometers.
Some believe the lost "Christie Lead" awaits rediscovery along the McDame Creek.