McDonough is a town in Chenango County, New York, United States.

[3] The town is named after Thomas Macdonough,[4] a naval officer who served on Lake Champlain and other locations.

McDonough is located in the western part of Chenango County, west of Norwich.

Calvary Episcopal Church was listed on the National Register of Historic Places in 1998.

New York State Route 220 is a highway following a meandering course through the town, leading southeast to Oxford and southwest to Smithville Flats.