Guilford is a census-designated place (CDP) in Chenango County, New York, United States.

It is located on County Road 35, which leads northwest 7 miles (11 km) to Oxford and southeast 10 miles (16 km) to Sidney.

According to the United States Census Bureau, the Guilford CDP has a total area of 1.5 square miles (3.8 km2), of which 1.4 square miles (3.5 km2) is land and 0.1 square miles (0.3 km2), or 8.12%, is water.

In the 2020 census, there were 322 people, 69 families, and 184 housing units.

[3] The ancestry of the CDP was 37.1% English, 32.1% Irish, 16.4% Polish, 15.1% American, 5.7% Scotch-Irish, and 5.0% Italian.