The McKinley River (Lower Tanana: Henteel no' Tl'o) is a 58-mile (93 km) tributary of the Kantishna River in central Alaska in the United States.

[3] It drains an area on the north slope of the Alaska Range on the south edge of the Tanana Valley southwest of Fairbanks.

[4] The river issues from Muldrow Glacier in the northern Alaska Range in Denali National Park and Preserve, northeast of Denali.

[4] It flows through the tundra north of the Alaska Range in a generally northwest direction, joining Birch Creek to form the Kantishna River near Chilchukabena Lake.

Other names or variants include Henteeth No' Tl'o and Hintusno' Dikats.