Once an important center of affluence and culture in colonial Prince William Parish (roughly analogous to modern-day Hampton County), McPhersonville is now little more than a marked location on a secondary road between Yemassee and Early Branch.
In 1682, the Proprietary County of Colleton was established, within which were later created Parishes of St. Bartholomew's (1706), Prince William (1745), St. Peter's (1747) and St. Luke's (1767).
In 1769, Beaufort District was created from the merger of three earlier parishes: St. Peter's, St. Luke's, and Prince William, the latter roughly corresponding to modern-day Hampton County.
McPhersonville proper was established by rice planters from along the Combahee and nearby rivers, who valued the inland area's cool winds, relatively low humidity and dense pine shade canopy.
The British left McPherson's Plantation and marched to the crossing of the Saltketcher (now the Salkehatchie) River, where a bridge had stood before the beginning of the war.
During the Civil War, McPhersonville was overrun early in the Carolinas Campaign by Union Maj. Gen. William T. Sherman's forces.
Prince William's strongest timbers were used to build bridges across the Combahee, and the Federals set fire to the rest.