After doing a number of one-off projects together, they teamed up to explore "a completely new realm of music" that they included on their self-titled debut album, released by Joyful Noise Recordings in association with a new sub-label called Stone Tapes, in 2022.
[1][better source needed] Before branching out as Medicine Singers, Daryl "Black Eagle" Jamieson, Ray Two Hawks, and other members of the original group had been providing drumming and singing music at New England pow wows and other gatherings.
[4] Preserving, reviving, resurrecting, and celebrating endangered Native American languages and dialects as well as maintaining aspects of ceremonial tradition and communion within these groups has always been a part of the band's mission.
"[5][6] Yonatan Gat saw Eastern Medicine Singers during an outdoor performance in Austin, Texas in 2017 and was so moved, that he spontaneously asked for them to come in and join him onstage at the show he was about to play.
[2] Ryan Olson was recruited as a producer, and a variety of other artists—Ian Wapichana of Wapishana, Joe Rainey Sr. of the Chippewa, Thor Harris of Swans, Jaimie Branch, Laraaji, and Ikue Mori, joined the project.