The series is produced and animated by TMS Entertainment and its subsidiary 3xCube and directed by Yō Moriyama, his first directorial work.

[2] Set in late 21st century Japan where boxers wear powered exoskeletons to fight, the narrative focuses on an underground fighter only known by his ring name Junk Dog, who decides to enter into a boxing competition called Megalonia, in order to defeat the champion, Yūri.

[3] The series was licensed by Viz Media for an English release and began airing on Adult Swim's Toonami programming block in the United States in December 2018.

The series was directed by Yō Moriyama who watched the second animated adaptation of manga Ashita no Joe during his youth.

He was shocked by the quality of the series, not only in animation but themes of "stray" portrayed Joe Yabuki's character as well as his rivalry with Toru Rikishi.

Originally, the story would take place in the same world as Ashita no Joe involving Jo's rival Rikishi but the idea was scrapped due to difficulties.

During this time, Moriyama became interested in moving images rather than drawing manga and joined studio Madhouse to develop anime, inspired by their work Bobby's Neck.

[15] Hip hop was Moriyama's favorite type of music which inspired the soundtrack of the series which he also thought would fit the setting of presented in the narrative.

Several of the fights presented in the anime are inspired by the Premier Boxing Champions matches that were recommended by the scriptwriter Katsuhiko Manabe.

[12] Producer Minako Fujiyoshi said he had no thoughts of giving Megalobox a second season during the finale of the first one due to lack of importance during such time.

[17] The staff had mixed thoughts about how they should handle Joe as a depressed adult despite his younger days as Megalonia's champion as that was how the first season ended.

Moriyama decided to touch new themes to make Megalobox become a more independent work rather than keep staying as a tribute to Ashita no Joe.

[20] Hosoya noted the response to the first season was not popular only in Japan but also Western regions as a result of the multiple letters the team received.

[24] The series was simulcasted on Crunchyroll; it aired for 13 episodes and the Japanese Blu-ray release contained a new short anime.

[26] Anime Limited announced that they had acquired the series for home video release in the United Kingdom and Ireland.

[37] Chikara Sakuma launched a manga adaptation of the Megalobox anime titled Megalo Box - Shukumei no Sōken (メガロボクス 宿命の双拳, "Megalo Box: The Twin Fists of Fate") which was serialized in Kodansha's Shōnen Magazine Edge from February 17, 2018, to August 17, 2018, with two published volumes.

[41] Similarly, Manga.Tokyo stated that despite the multiple flaws the anime suffers, it is still a great homage to Ashita no Joe and praised the handling of the main character whom the audience would cheer.

[43] Michael B. Jordan revealed that the emotional foundation for Joe's fights in Megalobox inspired the film Creed III.