Megalopyge uruguayensis is a moth of the family Megalopygidae.

The forewings are fuscous, shaded with grey about the tornus.

The veins are all white and there is a white shade at the end of the cell, joined by a postmedial white shade from the costa, partly cutting off a portion of the dark ground colour.

The hindwings are white with fuscous scaling on the inner margin and the terminal space is broadly fuscous, cut by white veins.

This article relating to the superfamily Zygaenoidea is a stub.