After graduating from high school, Stalter attended Sinclair Community College and later Wright State University, but left to try acting again.
[10][9] New York magazine named Stalter one of the "comedians you should and will know in 2019," and in 2020 The New York Times critic Jason Zinoman declared her "sketch comedy's newest star," writing, "In the constantly shifting ecosystem of young performers on Twitter and Instagram, the most vital voice to emerge during this anxious, isolating moment is that of Meg Stalter.
[10] The Los Angeles Times compared Stalter to other self-distributed comedians such as Cole Escola and Ziwe.
She is the voice of Bonnie Davis in the Paramount+ original series Tooning Out the News and plays Kayla in the HBO Max comedy Hacks.
[10] In 2023, she joined the cast of the film The Treasure of Foggy Mountain, playing park ranger Lisa, alongside X Mayo.