Mayo has acted in the series Strangers, The Good Doctor, and Swarm, and the films The Farewell (2019) and The Blackening (2022).
She moved to New York City to work in the makeup industry and went on to study improvisational comedy at Upright Citizens Brigade.
[3][4] Mayo produced and starred in the sketch comedy web series Who Made the Potato Salad, which co-starred other comedians of color.
[1] In 2019 she worked with Shenovia Large to host the comedy show "Unsung Heroes Of...", which was recommended by Time Out New York.
[9][10] In 2023, she joined the cast of the movie The Treasure of Foggy Mountain, playing park ranger Taylor, alongside Megan Stalter.