4 species (see text) Megastomatohyla is a genus of frogs in the family Hylidae.

[3] The generic name is derived from Greek mega (="large") and stem of the genitive stomatos (="mouth"), referring to the enlarged oral disc of the tadpoles, juxtaposed with Hyla, the genus in which the four Megastomatohyla species were previously placed.

[2] Megastomatohyla was erected in 2005 as a part of a major revision of the Hylidae and corresponds to the former "Hyla mixomaculata group".

The only tentative morphological synapomorphy of the genus is the greatly enlarged oral disc of the tadpoles, which has 7–10 anterior rows and 10–11 posterior rows—in those species where this trait is known.

[1] Megastomatohyla are small stream-breeding frogs, reaching a maximum snout–vent length of about 37 mm (1.5 in).