Mekdela (Amharic: መቅደላ) is a woreda in Amhara Region, Ethiopia.

Part of the Wollo, Mekdela is bordered on the southwest by the Walo Shabatala River which separates it from Sayint, on the west by Semien Gondar Zone, on the north by the Bashilo River which separates it from the Semien Wollo Zone, and on the east by Tenta.

Elevations in this woreda range from 700 meters above sea level where the Bashilo leaves it to 3600 meters at its southeastern point on the upper slopes of Mount Amba Ferit, Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 142,654, an increase of 34.03% over the 1994 census, of whom 69,626 are men and 73,028 women; 5,115 or 3.59% are urban inhabitants.

The majority of the inhabitants were Muslim, with 70.94% reporting that as their religion, while 28.88% of the population said they practiced Ethiopian Orthodox Christianity.

This article about a location in the Amhara Region of Ethiopia is a stub.