The first written appearance of the village Melambes is attributed to Francesco Barocci (1537-1604) at 1577 and at the Venetian Census of 1583 it was reported to have a population of 338 people.

Emmanuel, Aggelis, George and Nikolaos Vlatakis, born and lived in Melambes, also participated in the battle and openly declared their faith to the Christian God.

Turks arrested them for declaring their faith and after four months of imprisonment and torture to renounce the Christian God, they were executed at the Big Gate of Rethymno City at October 28, 1824.

[4] Other inhabitants of Melambes participated at the Cretan Revolt (1866–1869) in battles in the local region, Rethymno, Sfakia, Amari and Messara.

High school students need to travel to the near-by village of Spili or Rethymno city to attend classes.