Melanophryniscus biancae is a species of toads in the family Bufonidae, first found in the Atlantic Forest in Santa Catarina, Brazil.

It is found at intermediate-high altitudes and has a phytotelm-breeding reproductive strategy.

It is distinguished from its cogenerate species based on differences in snout-vent length; having white and/or yellow spots on its forearms, mouth, belly and cloaca; the pattern and arrangement of warts; and the presence and number of corneous spines.

It might be threatened by habitat loss.

[1][2] It was named in honor of Bianca Reinert due to her conservation efforts.