Melanophryniscus klappenbachi, also known as Klappenbach's red-bellied frog, is a South American species of toad in the family Bufonidae.

It is found in the Gran Chaco in northern Argentina, Paraguay, and Brazil (Mato Grosso do Sul), and possibly in Bolivia.

[3] Its natural habitats are shrublands, and it can also be found in disturbed areas such as livestock farms.

When fed diets with low levels of alkaloids, there was a decrease in the amount of this toxin produced.

[4] Melanophryniscus klappenbachi is a common species facing no significant threats.