Melbourne City's first A-League Men match was against the Central Coast Mariners, and they met their 14th and most recent different league opponent, Macarthur FC, for the first time in the 2020–21 A-League season.
The team that Melbourne City have played most in league competition is Adelaide United; who they first met in the 2010–11 A-League season.
The 18 defeats from 42 meetings against Perth Glory is more than they have lost against any other club.
Adelaide United have drawn 13 league encounters with Melbourne City, more than any other club.
Melbourne City have recorded more league victories against Brisbane Roar than against any other club, having beaten them 21 times.