She previously served as an associate judge of the Rhode Island District Court from 2019 to 2025.

From 2008 to 2019, DuBose was recruited to be the U.S. legal counsel for Schneider Electric, where she worked in corporate compliance, ethics, and fair trade.

In 2019, she was appointed by Governor Gina Raimondo to the Rhode Island District Court.

On February 1, 2024, President Biden nominated DuBose to a seat being vacated by Judge William E. Smith, who subsequently assumed senior status on January 1, 2025.

[7] During her confirmation hearing, she was questioned by Senator John Kennedy over an article from 2000 in which DuBose was quoted about Marxism.