Melnea Cass Boulevard is a major street in Boston, Massachusetts,connecting Dudley Square in Roxbury to the South End.

Named after prominent community and civil rights activist Melnea Cass, the boulevard has historical roots as part of the proposed—but ultimately canceled—Interstate 695 (the Inner Belt).

The boulevard begins at its eastern terminus at the Mass Ave Connector and continues westward, intersecting several major thoroughfares in Roxbury, as well as a few smaller streets.

Its history as a planned right-of-way for the Inner Belt[1] contributes to its unique character: it is largely devoid of buildings, except for a few city-owned properties built on previously vacant lots.

[2] Due to its concentration of service providers, the area around the "Mass and Cass" intersection has attracted a large number of people dealing with homelessness and drug addiction, especially after the closure of the treatment facility on Long Island.