Melrose-Mindoro High School is a public high school located at N181 State Rd.108, Melrose, Wisconsin 54642-8284.

It is a rural district located in Southwestern Wisconsin, serving approximately 700 students.

The district is located approximately 25–30 minutes from Black River Falls, Sparta, and La Crosse.

[3] The district mascot is the Mustang.

This Wisconsin school-related article is a stub.