TIRR Memorial Hermann rehabilitation hospital is also located in the Texas Medical Center.

Affiliated physicians performed the first in utero spina bifida surgery in Texas after the MOMS trial, an NICHD-sponsored study of prenatal and postnatal closure of myelomeningocele.

The institute has 140 neuro beds and five dedicated operating rooms It was the first neurosurgery center in Texas to offer microsurgery, interventional neuroradiology/endovascular surgery and gamma knife radiosurgery.

Dr. James Grotta was principal investigator in Houston for the first major trial showing benefits of clot-busting drug tissue plasminogen activator (tPA).

[6] In 2012, U.S. News & World Report named TIRR Memorial Hermann to the list of America's Best Hospitals for the 23rd consecutive time.

In 2010, Memorial Hermann–Texas Medical Center was ranked in 4 adult and 1 pediatric specialties by the U.S. News & World Report.