The Shriners Hospital for Children (Houston) was a non-profit, 40-bed pediatric orthopedic hospital, research and teaching center located in the Texas Medical Center in Houston, Texas, United States.

Faculty worked closely with the Baylor College of Medicine, Scott and White Hospital, and the University of Texas Health Science Center at Houston.

[1] Prior to Hurricane Ike in 2008, the cleft lip and palate program had been based at the institution's sister hospital, Shriners Hospital for Burned Children in nearby Galveston.

[2] When the Galveston hospital reopened in 2009, the decision was made to keep the cleft lip program in Houston.

The merger was expected to be completed by the 4th Quarter of 2020 with the closing of the Houston Hospital occurring in early 2021.