[3][4] The hospital was first established as the Colorado Conference Deaconess Hospital and Training School of the Methodist Episcopal Church in 1904 by members of the Woman's Home Missionary Society of the Colorado Springs First Methodist Episcopal Church and other members of the community who saw a need for a Protestant hospital in the city.

Its first location was in a wooden building at the intersection of South Institute Street and East Colorado Avenue.

In 1943, the city of Colorado Springs purchased the hospital and renamed it Memorial Hospital and Beth-El School of Nursing of Colorado Springs.

Voting on a referendum in 2012, the citizens of Colorado Springs agreed to lease the hospital to UCHealth for forty years, and it was renamed UCHealth Memorial Hospital.

[5] Later, the name changed to Memorial Hospital Central to differentiate it from Memorial Hospital North, which is located on Briargate Parkway north of Colorado Springs.