In April 2004, the hospital was designated a Level II trauma center by the Colorado Department of Public Health and Environment[2] and it later was also recognized by the American College of Surgeons in October 2005.

[5] On December 6, 2004, Littleton Adventist Hospital announced that it would expand for $38 million, by adding three stories to its south tower.

[13][14] By April 2019, the hospital had one million patients visit the emergency department, it delivered 50,000 babies, and performed 165,000 surgeries.

[17][18][19] In early September 2023, construction workers began building a three story, 97,700-square-foot, heart and vascular tower for $100 million.

[20][21] On May 15, 2024, AdventHealth Littleton announced that employees had found thirty-one cremains from miscarriages, they were later buried at a local cemetery.