Generally, in between overpasses, there exists a pair of entrance and exit ramps that allow traffic to transition between the limited-access lanes and the parallel frontage road.

The frontage roads do not exist between the University Drive and Clinton Avenue overpasses; here through traffic must merge into the limited-access lanes.

Most of the non-limited access portions within the Huntsville city limits consist of six through lanes, three in each direction, separated by a median.

Memorial Parkway passes to the east of a Sanmina-SCI Corporation production plant, crossing over Green Cove Road.

Continuing due north, the Parkway passes Mountain Gap Road and Meadowbrook Drive.

This overpass was originally constructed to provide a convenient U-turn as well as allow quicker access to businesses alongside the Parkway.

The Parkway continues north with at-grade intersection at Mastin Lake Road, which is planned to have an overpass built by 2021.

With the establishment of the U.S. Army Missile Command at Redstone Arsenal, and the NASA Marshall Space Flight Center in the 1960s, Huntsville underwent massive population growth, and, as a result, traffic increased.

The interchange includes a mix of cloverleaf and fly-over ramps to provide full merge-in and merge-out access to both routes.

As part of this construction, the original Clinton and Holmes overpasses were torn down and replaced with wider ones incorporating the necessary merge lanes.

The City of Huntsville is planning construction of a multi-modal bridge to be used by for pedestrians and bicyclist to cross over Memorial Parkway between the interchanges of Holmes Avenue and Governors Drive.