Continuing east, University Drive passes through multiple shopping centers and car dealerships.

University Drive meets Research Park Blvd / Alabama 255 with a six-ramp partial cloverleaf and passes just to the north of MidCity Huntsville, formerly Madison Square Mall.

An overpass over Sparkman Drive with on- and off-ramps provides access to the University of Alabama in Huntsville.

Following the interchange, the road runs under a pedestrian and bicycle bridge and then meets Alabama 53 / Jordan Lane.

Shopping Centers:[5] Major retail stores include: Access to shuttle buses provided by the city of Huntsville are available along University Drive.