When Rabbi Joseph Caro, shortly before his death (1575), sent Kesef Mishneh, his commentary on Maimonides' Yad ha-Ḥazaḳah, to Mantua for publication, Fano, at the suggestion of Dei Rossi, assumed part of the expense and took charge of the edition.

Fano's authority as a Talmudist is evident in a collection of responsa ("She'elot Teshubot me-Rabbi Menaḥem 'Azaryah," Dyhernfurth, 1788) containing 130 chapters on various subjects connected with religious law and ritual questions.

In his love for precision and brevity Fano compiled a book of extracts from Alfasi's code, which itself is only a compendium of the Talmud.

Ten of these are comprised in the work "'Asarah Ma'amarot"; five of them, under the title "Amarot Ṭehorot," were printed together with "Ḳol Yehudah," a philosophical commentary by Judah ben Simon (Frankfort-on-the-Main, 1698; Mohilev, 1810).

"[1] The following teaching is characteristic of the author's optimism as well as of his mild nature, which attracted the sympathy of all: In 1581 Jedidiah Recanati dedicated to Fano his Italian translation ("Erudizione dei Confusi") of Maimonides' "Moreh Nebukim."

Isaiah Hurwitz especially mentions Fano's treatise "Yonat Elem" as a theological work the teaching of which comes very near to the truth (Joseph Solomon Delmedigo, introduction to "Nobelot Ḥokmah").