Mesena is an unincorporated community in Warren County, Georgia, United States.

The community is located near the county's eastern border with McDuffie County, 5.5 miles (8.9 km) northeast of Warrenton.

Mesena has a post office with ZIP code 30819.

[2][3] Mesena is said to have been named by J. F. (or J. H.) Hamilton, who coined it from the initial letters of the first names of his six daughters (Mary, Evelyn, Sara, Emily, Nancy, and Ann).

This Warren County, Georgia state location article is a stub.