[2] M. nitroreducens is one of only two organisms that are currently known to be able to couple methane oxidation with nitrate or nitrite reduction, the other being Methylomirabilis oxyfera.

[3] It has been suggested that AOM is facilitated by Borgs, unusual large extrachromosomal DNA elements found in Methanoperedens.

[1][5] M. nitroreducens is more likely to exist and be competitive in an environment enriched in nitrate as opposed to sulfate or other potential terminal electron acceptors.

[5] Requiring both methane and nitrate, this organism is commonly found in the area between oxic and anoxic zones.

M. nitroreducens was first described by Haroon et al. in 2013 after adding methane, ammonium, and nitrate to a bioreactor, which led to a single organism proliferating.