Propyne can also be synthesized on laboratory scale by reducing 1-propanol,[4] allyl alcohol or acetone[5] vapors over magnesium.

Their research showed[citation needed] that propyne would be highly advantageous as a rocket fuel for craft intended for low Earth orbital operations.

[7] Whereas purified propyne is expensive, MAPP gas could be used to cheaply generate large amounts of the reagent.

[10] Propyne has been detected in multiple astrophysical objects following its first observation in 1973 in the galactic center giant molecular cloud Sgr B2 using radio astronomy techniques.

[12] Propyne has been detected by infrared spectroscopy in the chemically reducing atmospheres of the outer planets in our solar system, including on Jupiter in 2000 [13] and on Saturn in 1997,[14] both using the Infrared Space Observatory; on Titan in 1981 using Voyager's IRIS instrument;[15] and on the ice giants Uranus in 2006 [16] and on Neptune in 2008 [17] using the Spitzer space telescope.