The town council asked the State Railways for a station to be built west of the Erms.

Instead the tracks were laid to the east of town to allow a better alignment and to facilitate the connection of the projected railway line towards Urach.

The railway to Urach, with a possible continuation to Münsingen planned, was opened from a junction in Metzingen on 27 December 1873.

This line was initially operated by the private Ermsthalbahn-Gesellschaft ("Erms Valley Railway Company").

On 8 November 1912, the council complained about the entrance building, the size of which, in their opinion, was no longer sufficient.

Farmers mainly loaded fruit, vegetables, wine, beef, pork and lumber.

The station's operations area received a small locomotive for the shunting of freight trains.

In 1959, one hundred years after the opening, 130 trains stopped at or passed through Metzingen each day.

Since the timetable change on 13 December 2009, a pair of InterCity trains has stopped in Metzingen.

The unused goods shed was demolished in June 2011 to create a site for a commercial building and parking.

Deutsche Bahn is planning a series of changes in the station and the rebuilding of a dismantled track.

On the ground floor there were 2nd and 3rd class waiting rooms, as well as premises for the railway and the post office.

The 15.5 metre-long and 14.32 metre wide single-storey annexe to the south was built for the handling of baggage and express freight.