A significant portion of this bypass has been on hold since 2010, even though the Veracruz state government spent 154 million pesos on it between 2010 and 2015.

[5] The Highway 180D designation is also applied to a toll road between Nuevo Teapa and Cosoleacaque in the southern portion of Veracruz.

[2][6] The only segment signaged Highway 180D in Tabasco begins almost immediately after crossing from Veracruz, at Agua Dulce.

[11] The Champotón-Campeche highway is operated by Caminos y Puentes Federales (CAPUFE) and has a total length of 39.5 kilometres (24.5 mi).

Proceeding southwest, the next interchange is at Seybaplaya and is immediately followed by a toll plaza booth, the only one on the road.

Almost immediately, it has an interchange at the southern end of Yucatán State Route 53, connecting to Izamal, and an option to merge back onto Highway 180 toward Holca.

Highway 180D crosses into Quintana Roo north of Nuevo X-can in Lázaro Cárdenas Municipality.

East of here is its interchange with Highway 305D and its toll extension, connecting to Quintana Roo State Route 5 to the north and Playa del Carmen to the southeast.

Travelers heading eastbound have the option to merge with non-toll Highway 180, which becomes Avenida López Portillo in Cancún, or to make a right turn and follow Quintana Roo State Route 180 toward Highway 307 with access to the Cancún International Airport.

[16] The Autopista Mérida-Cancún was formally opened on December 23, 1991, by President Carlos Salinas de Gortari.