The line was inaugurated in 1983 and it runs from northwest to northeastern Mexico City.

[1] Line 6 was opened on 21 December 1983, in the section that goes from El Rosario, serving the estate Unidad Habitacional El Rosario -the biggest estate in the country, to Instituto del Petróleo.

According to the Mexico City Metro Plan published in 2018 by the Sistema de Transporte Colectivo, Line 6 would be expanded from Martín Carrera eastbound towards Villa de Aragón station of Line B.

[3] Line 6 has had different types of rolling stock throughout the years.

As of 2020, out of the 390 trains in the Mexico City Metro network, 17 are in service in Line 6.