Mezhova Raion (Ukrainian: Межівський район) was a raion (district) of Dnipropetrovsk Oblast, southeastern-central Ukraine.

Its administrative centre was located at the urban-type settlement of Mezhova.

The raion was abolished on 18 July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Dnipropetrovsk Oblast to seven.

At the time of disestablishment, the raion consisted of three hromadas:[4]

Ivan Chernoknizhny (1890-1928) – anarchist in the Revolutionary Insurgent Army of Ukraine (RIAU) under Nestor Makhno was native to the region.