It is the meridian road dividing the street grid of Miami and Miami-Dade County into east and west avenues.

The southern terminus is on South Bayshore Drive in the Coconut Grove neighborhood of Miami at Alatka Street/Mercy Way in front of Mercy Hospital.

It is one way southbound from North 17th Street to the Miami River downtown where it curves onto South First Avenue.

In 2022, Miami-Dade County commissioners and the City of Miami co-designated a stretch of South Miami Avenue (from Southeast 15th Road to Southeast 13th) as Alicia Cervera Way, honoring the Peruvian-American businesswoman and real estate figure.

[3][4][5] Miami Avenue is the dividing line between Northwest and Northeast streets.