Originally tapped to work as a story editor, he rose fairly quickly through the ranks, thanks in part to his mentor, chairman and co-founder of New Line Cinema Robert Shaye.

De Luca co-wrote the story for the 1995 film adaptation of the popular British comic book character Judge Dredd, starring Sylvester Stallone as the eponymous lead.

[4] In 1996, De Luca, was approached by the producers Brannon Braga and Ronald D. Moore for Star Trek: Voyager and pitched an idea which turned into an opportunity to write an episode for the series, Threshold.

During his tenure at New Line Cinema, he oversaw a variety of films that would come to define the studio, including Seven, Friday, Boogie Nights, Austin Powers, Rush Hour, Blade, American History X, and Magnolia.

De Luca also produced the 2011 remake of the cult classic vampire horror film Fright Night.

[9] In 2009, he married actress Angelique Madrid (born 1974) from Ft. Worth, Texas, who was a contestant on the first season of ABC's The Bachelor.